The PRIP2021 Motto is: “Artificial Intelligence: Facing the Challenges”. Despite the problems with COVID19, we objectively assess the importance of this topic. The concept of AI has already become closely intertwined in our daily life. However, there is still no consensus on whether all tasks can be solved using these technologies. Abuse or obligatory use - we will raise such issues of ethics, modern information society, and cybernetics. Your successful AI use cases (but not just AI), including in the fight against the pandemic, is the story of our conference in 2021.